Cleopatra, Jeanne D'Arc, Elizabeth I, Katharina the Great, Luise von Preußen and Sophie Scholl -- they are all women from strongly contrasting eras and with different backgrounds - but they have one thing in common: they are among the most influential women in history. Powerful and helpless, popular and despised, determined and desperate. The documentary portrays these remarkable women in unprecedented detail and examines their lives both in the contemporary context, as well as from a historical perspective.